2023 Open House – COR²E – UConn Center for Open Research Resources & Equipment

Fall 2023

COR²E Facility Open House & Vendor Show

Monday, October 2, 2023
11am to 1pm

Storrs Student Union Grand Ballroom (Rooms 330-331)

Full lunch buffet provided by our vendor sponsors

Experience COR²E

Join the Center for Open Research Resources & Equipment (COR²E) on Monday, October 2, 2023 for an informational Open House that will highlight the valuable research resources and expertise available within COR²E to support UConn Research. This event will give you the opportunity to meet our Facility Directors and Scientists and learn about many new capabilities, services, and instrumentation. We’ve invited our facility colleagues from the Health Center Research Advisory Council (HCRAC, UConn Health) to join us as well. Stop by for lunch sponsored by some of our participating vendors, initiate stimulating conversations with core experts, and use this time to meet representatives from your favorite scientific product vendors. In order to help us plan appropriately for this event, please register in advance for this event using the "Register" link below.

Participating COR²E (Storrs) Facilities

Advanced Light Microscopy Facility (ALMF)

BioSupply

Biophysics

Digital Experience Group (DXG)

The Digital Experience Group (DXG) offers UX Design, Web Development, App Development, Web Design, and other digital innovation in support of Research at UConn. Primarily staffed by student designers, developers, and writers, the DXG also strives to serve as a source of experiential learning, utilizing industry-leading approaches to UX, agile software development, and product design.

In addition to providing services to PIs and other research centers at UConn, the DXG contains the specialized Squared Labs team, which provides web development and digital services in support of the University's research infrastructure.

Electrical/Electronics: Technology & Repair

Flow Cytometry

The Flow Cytometry Facility provides investigators with expertise and sophisticated instruments for the analysis of cells or particles based on size, internal complexity, and fluorescent signals. Cytometers allow simultaneous analysis of multiple properties of cells or particles and provide information about both single cells and populations. The heterogeneous cells and populations can be identified and quantified. Selected cells or particles can also be physically sorted to obtain pure populations for further analysis or subsequent culture and functional study.

Mechanical/Glass: Design & Fabrication

Mechanical/Glass: Design & Fabrication Facility supports academic research through consultation, engineering, manufacturing, design, and repairs. Within the facility, there are complete departments for working with glass, metal, plastics, and other materials. Skilled technicians design, fabricate, or repair complex mechanical instruments and glassware, and carry out jobs in precision machining, MIG and TIG welding, woodworking, sheet metal, and plexiglass fabrication.

Microbial Analysis, Resources and Services (MARS)

Nuclear Magnetic Resonance (NMR)

The Nuclear Magnetic Resonance Facility recognizes the important role that NMR plays in molecular structure determination and conformational analysis for research projects engaging chemical synthesis, chemical mixture characterization, drug design, intermolecular interaction studies, protein and nucleic acid characterization. The joint NMR Facility of COR²E and the Department of Chemistry offers several solution-state NMR instruments on a fee-for-use basis. The instrumentation serves the high-resolution research needs for investigators from the University of Connecticut and nearby colleges and companies.

Proteomics & Metabolomics Facility (PMF)

Statistical Consulting Services (SCS)

Participating HCRAC (UConn Health) Facilities

CCAM Microscopy Facility

The CCAM Microscopy Facility provides the UConn Health research community as well as other academic and industrial institutes, access to its state-of-the-art equipment for quantitative fluorescence imaging applications. Within the facility, there are two laser scanning confocal microscopes equipped with 34-channel high-efficiency QUASAR detectors. One of these microscopes supports nonlinear optical (also known as 2-photon) excitation, fluorescence correlation spectroscopy (FCS), and fluorescence lifetime imaging microscopy (FLIM). Additionally, there is a light sheet microscope available for micro/meso scale 3D imaging. Furthermore, the facility recently acquired a state-of-the-art Zeiss Elyra 7 microscope that is capable of total internal reflection fluorescence microscopy (TIRFM) and supports several super-resolution techniques such as lattice structured illumination microscopy (SIM), stochastic optical reconstruction microscopy (STORM), 3D photoactivated localization microscopy (PALM), and DNA points accumulation for imaging in nanoscale topography (DNA-PAINT).

Cell and Genome Engineering Core

The University of Connecticut Cell and Genome Engineering Core has substantially contributed to Stem Cell Research conducted in Connecticut and beyond by providing a central source of technologies and materials for research on human pluripotent stem cells: embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC). The Genome Editing arm of the Core uses cutting edge genome engineering technologies to develop cellular models.

Center for Genome Innovation (CGI)

The mission of the CGI is to provide state-of-the-art expertise in genome technologies while facilitating genomics research for faculty and students across the University of Connecticut campuses.

CGI's infrastructure serves as a nexus for computational biology support and maintains a diverse portfolio of genomics instrumentation from microfluidics, arrays and next generation sequencing. Support for these technologies are in the form of experienced user access, hands-on assistance, training and/or consultation through the CGI.

Center for Mouse Genome Modification

Computational Biology Core (CBC)

The Computational Biology Core (CBC) housed in the Institute for Systems Genomics at the University of Connecticut provides computational power and technical support to UConn researchers and affiliates. We collaborate with the Center for Genome Innovation (CGI) and Proteomics & Metabolomics Facility (PMF, Storrs campus COR²E Facility) to provide full support to the research community.

Electron Microscopy Facility

The Central Electron Microscope Facility (CEMF) is a UConn Health-supported research facility providing electron microscopy research service for faculty, students and extramural users. The CEMF occupies approximately 1,800 sq. ft. of space on B level of the main UConn Health building (rooms AB027 and AB031). The CEMF has three recently installed electron microscopes (EMs) equipped with digital imaging capabilities: a Hitachi H-7650 transmission EM, a JEOL JSM-5900LV scanning EM and a Zeiss Sigma Gemini HV field emission Scanning EM. Sample preparation instruments include ultramicrotomes, vacuum evaporator, sputter coater, critical point dryer, high pressure freezer, freeze substitution system and ion beam coater. The electron microscopes and other instruments also are available for use by experienced faculty or students. During the Fall of 2023, the facility will be installing a Thermo Fisher Tundra cryo-EM and a Zeiss Sigma 360 scanning EM equipped with an energy dispersive spectroscopy probe. These instruments will greatly enhance the capabilities of the EM facility.

Fluorescence Activated Cell Sorter (FACS) Facility

The UConn Health Flow Cytometry facility provides flow cytometric analysis and cell sorting services to all UConn researchers as well as researchers at neighboring institutions. The UConn Health Center Flow Cytometry Facility has six instruments available for cellular analysis and two cell sorters. There are three Becton Dickinson (BD) LSR II instruments, an automated high-throughput Bio Rad ZE5, an Accuri C6 analyzer, and an Amnis ImageStream Mark II. Cell sorters include two BD FACS ARIA II high speed cell sorters.

MicroCT Imaging Facility

The microCT Imaging Facility specializes in quantitative 3-dimensional imaging using x-rays. Our most common projects involve morphometric and densitometric analyses of mineralized tissues from model organisms. In addition to bones and teeth, we provide nondestructive scans of biomaterials, museum artifacts, and industrial products with micrometer-scale resolution. We operate 3 Scanco µCT instruments and have an arrangement of micromechanical testing devices to allow detailed assessment of structure and function.

NMR Structural Biology and Biophysical Core

The NMR Facility provides a state-of-the-art environment for studying the structure, dynamics, folding, and interactions of biological macromolecules. The primary goal of the facility is the application of advanced NMR techniques to important and challenging biomedical problems. To meet these challenges, facility staff adopt state-of-the-art methods and develop new methods to enhance and facilitate bio-molecular applications of NMR, including structural biology, interaction screening, and metabolomics.

Research Histology Core